Current Issue : October-December Volume : 2023 Issue Number : 4 Articles : 4 Articles
In this work new biphenyl ether derivative of paracetamol were synthesized by reacting paracetamol with iodobenzene to get A1, further treated with various aldehyde to get compounds A2-A6. Lead compounds were characterized by melting point, TLC, elemental analysis, IR, 1H-NMR and mass spectral data. All the synthesized compounds were screened for in-vitro anti-inflammatory, anti-TB and anti-oxidant activity....
In this work new derivatives of salicylic acid were synthesized by hydrazonolysis of methyl salicylate and hydrazine hydrate to get C, further treated with various aromatic aldehydes to get compounds C1-C5. Lead compounds were characterized by melting point, TLC, elemental analysis, IR, 1H-NMR and mass spectral data. All the synthesized compounds were screened for in-vitro anti-inflammatory, anti-oxidant activity and anti-tubercular activity....
In this work new derivatives of Salicylic acid were synthesized by ullmann condensation of Schiff bases and salicylic acid or methyl salicylate to get B1-B3, the Schiff bases are prepared by 3-chloro-4-fluroanile is treated with various aromatic aldehydes to get compounds A1-A2. Lead compounds were characterized by melting point, TLC, elemental analysis, IR and 1H-NMR spectral data....
Schiff base derivatives have emerged as a versatile class of compounds with diverse applications in various fields, including medicinal chemistry and materials science. This research highlights the synthesis, purification and characterization of Schiff base derivatives through recrystallization and infrared (IR) spectroscopy. The synthesis of Schiff base derivatives involves a condensation reaction between an amine and an aldehyde or ketone, resulting in the formation of an imine linkage. These compounds exhibit unique properties, such as chelation, coordination and metal-binding capabilities, making them valuable in developing novel materials and functional molecules. However, the synthesis of Schiff bases often yields impure products, necessitating purification techniques for isolation and subsequent characterization. Recrystallization, a widely employed purification method, entails dissolving the crude product in a suitable solvent and allowing it to slowly crystallize. This process facilitates impurity removal, yielding highly pure Schiff base derivatives. The choice of solvent, temperature and crystallization conditions significantly influence the success of recrystallization and the obtained crystal quality. Following purification, characterizing Schiff base derivatives is crucial to confirming their structural integrity. Infrared spectroscopy (IR) is a powerful analytical technique used for this purpose. IR spectra provide valuable information about the functional groups present in the compound, enabling the identification of characteristic peaks associated with the imine linkage and other relevant chemical moieties. By comparing the experimental spectra with reference data, the structural identity and purity of Schiff base derivatives can be determined. The synthesis, purification through recrystallization and characterization using IR spectroscopy are essential steps in studying Schiff base derivatives. These techniques enable the production of pure compounds and provide valuable insights into their structural features, facilitating their application in various scientific and technological domains....
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